Research Programs
 
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Analytical Chemistry
 
  Atomic spectroscopy; sample introduction methods for atomic sources; automation in chemical analysis; analytical techniques for environmental pollutants and food additives; capillary and microchip capillary electrophoresis; biological mass spectrometry in proteomics applications.


Chemical Biology
 
  Structure determination of biomolecules; interaction, dynamics and functional studies of biomolecules and drugs (and metallodrugs); development of new experimental and computational methods for high throughput structure determination of biomolecules by NMR spectroscopy.

DNA condensation by nanopolymer
 
(I) Schematic illustration of the nanopolymer structure
   
(II) The globular morphology of the nanopolymer/DNA polyplexes as observed under the transmission electronic microscope (TEM)

 
(I) In vitro transfection efficiency of the nanopolymer carrying the EGFP plasmid in cells;
   
(II) In vivo transfection efficiency of the nanopolymer carrying the firefly luciferase plasmid (pLuc) in mice. Bioluminescent imaging of luciferase expression was determined and quantified in living mice using a cooled CCD camera at 24 hours after intravenous injection of the nanopolymer/pLuc polyplexes


Inorganic Chemistry
 
  Inorganic and organometallic photochemistry (including studies in microheterogeneous media); asymmetric synthesis and organic oxidation using metal complexes; structure and properties of high nuclearity metal clusters; biomimetic models for nitrogen transfer reactions; chemistry of lanthanides; metal-alkylidyne and -alkylidene complexes; metal-protein interactions; supramolecular chemistry; molecular recognition and chemosensing; recognition and cleavage of DNA by metal complexes; molecular metal-based materials with novel properties.
Intermolecular hydrogen-bonded 1D chain of novel pentameric water cluster running along the crystallographic b-axis in complex 2


Materials Science
 
  Light emitting materials; nanoparticles; catalysts and materials for green oxidation; materials for organic solar cells.


Organic Chemistry
 
  Organic Chemistry Synthetic organic chemistry: new synthetic methods, asymmetric catalysis, total and enantioselective synthesis of natural products; chemical biology of natural products; chemical and biological oxidation reactions; design, synthesis and applications of foldamers and peptidomimetics; drug design and synthesis.
1 Merged image, co-stained with three probes
2 DAPI (for nuclei, blue color)
3 HKGreen-4 (for ONOO-, green color)
4 MitroTracker ® Red CMXRos [M7512] (for mitochondrion, red color)


Polymer Chemistry and Synthesis
 
  Synthesis and characterization of polymers with potential applications in photonics, electronics, and organic transformations.
 


Physical Chemistry
 
  Molecular simulation: Monte Carlo and molecular dynamics calculations; electrochemistry: scanning probe microscopy, fuel cells and sensors, advanced lithium battery, electroplating techniques; molecular reaction kinetics and dynamics; solution phase chemical dynamics; theoretical investigation of electrical and optical properties of polymeric materials; theoretical and computational biophysics including protein folding and charge transfer in biomolecules; reaction mechanisms and chemical intermediates; physical organic chemistry; energetics, structures and mechanisms of gas-phase ions fragmentation.
DNA base adenine   DNA oligomer A20


Spectroscopy/Spectrometry
 
  High resolution laser and IR spectroscopy; NMR: new pulse sequences employing magnetic field gradients; ultrafast time-resolved spectroscopy; time-resolved resonance Raman spectroscopy; mass spectrometry.


X-Ray Crystallography
 
  Structural chemistry, solid-state chemistry.


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